here's the list we have experience with lscache:
https://www.litespeedtech.com/support/wiki/doku.php/litespeed_wiki:cache:lscache
enabling lscache for particular URL is relatively easy, but the difficult part is business logic:
- which URL under which condition can be cached or can't
- may need additional php addon or plugin to have lscache working as expected.
this is common for all cache solution, include varnish, those cache plugins for wordpress(W3 Total cache, WP super cache etc)
this apply to drupal as well. general speaking,
if you can find a varnish cache solution for drupal, most likely you can set up lscache for drupal based on the varnish cache rule.
and this is just how we've worked out lscache for vBulletin which is included in above cache list wiki.