The location of each individual Vhost template and vhost configuration file are configurable, you don't have to put it under lsws/conf, you can put them anyway.
The list is stored in lsws/conf/httpd_config.xml, cannot be moved.
There are performance issue with serving files from a nfs partition for single-thread, event driven web servers due to the high latency of blocking I/O operations. It is not LiteSpeed specific issue though. AIO for nfs is not supported by Linux, and the only way to deal with it is to use a N-CPU license to compensate it, I think at least 4-CPU and above can bring good performance out of this kind of setup.