Are you running cPanel and their default cipher suite? If so, Apache and older version of LSWS does not support "CHACHA20-POLY1305", so this configuration has no effect, so the default Apache cipher suite is used and it includes "ECDHE-RSA-AES128-SHA". While the latest builds of LSWS support using the new BoringSSL package which supports "CHACHA20-POLY1305" and TLSv1.3, so the configuration actually applied which resulted in IE 11 and other older browsers not successfully negotiating a SSL cipher with the latest version of LSWS. The fix is simple, just add "ECDHE-RSA-AES128-SHA" to the end of the cipher list and shouldn't see the handshake failures anymore. This is a cPanel issue that we have reported to them.