I'm not sure what causes it. This is a recently launched new VPS. The users are moved from an older VPS (also running litespeed). They are moved via the Directadmin export / import function.
I have a feeling it has something do to "private_html". As that is not being used anywhere, but it appears in all affected urls.
All websites have "Use a symbolic link from private_html to public_html - allows for same data in http and https"
All process contain "private_html":
lsphp:lve12/domains/aaaaa.eu/private_html/index.phto_avoid_overwrite_important_env
lsphp:lve12/domains/aaaaa.eu/private_html/index.phto_avoid_overwrite_important_env
lsphp:e12/domains/aaaaa.eu/private_html/wp-cron.phto_avoid_overwrite_important_env
lsphp:aaaaa.eu/private_html/wp-admin/admin-ajax.phto_avoid_overwrite_important_env
lsphp:bbbbb/domains/bbbbb.nl/private_html/index.phto_avoid_overwrite_important_env
lsphp:bbbbbb/domains/bbbbb.nl/private_html/index.phto_avoid_overwrite_important_env
lsphp
mains/ccccc.nl/private_html/index.phto_avoid_overwrite_important_env
lsphp:mains/ddddd.nl/private_html/wp-cron.phto_avoid_overwrite_important_env